N-Acetyl-L-cysteine Singlet oxygen

Devasagayam, T.P.A.; Sundquist, A.R.; Di Mascio, P.; Kaiser, S.; Sies, H.
J. Photochem. Photobiol., B 9, 105-116 (1991)

Reaction: N-Acetyl-L-cysteine + ¹O₂^* ® products
Reference Reaction: CysSH + ¹O₂^* ®
Solvent: D₂O

k_react = 6 × 10⁵(L mol^-1 s^-1), k_reference = 8.3 × 10⁶(L mol^-1 s^-1), pH = 7.4, T = 310K

Experimental method: Chemical reaction
Analytical method: chemical analysis
Data type: Relative value measured by steady state method

¹O₂* from NDPO₂.

Devasagayam, T.P.A.; Sundquist, A.R.; Di Mascio, P.; Kaiser, S.; Sies, H.
J. Photochem. Photobiol., B 9, 105-116 (1991)

Reaction: N-Acetyl-L-cysteine + ¹O₂^* ® products and/or physical quenching
Solvent: D₂O

k = 6 × 10⁵(L mol^-1 s^-1), pH = 7.4, T = 310K

Experimental method: Chemical reaction
Analytical method: infrared luminescence
Data type: Derived from steady state measurements

used solvent k_d = 1.9 × 10⁴ s^-1; ¹O₂* from NDPO₂.

Rougee, M.; Bensasson, R.V.; Land, E.J.; Pariente, R.
Photochem. Photobiol. 47, 485-489 (1988)

Reaction: N-Acetyl-L-cysteine + ¹O₂^* ® products and/or physical quenching
Solvent: D₂O

k £ 4 × 10⁴(L mol^-1 s^-1)

Experimental method: Flash photolysis
Analytical method: infrared luminescence
Data type: Derived from pH study

Photosensitizer = H₂TPPS^4- or H₂TMpyP⁴⁺; calcd. from k_obs = 2.5 × 10⁶ at pH 7 and pK_a(D₂O) = 10.0.